Misaki Mei is the female protagonist of Another and a student of Class 3-3 at Yomiyama North Middle School in 1998. She was labeled by her classmates as "the one that does not exist."

Mei was born like the older of two twin girls, she was originally conceived by Mitsuyo Fujioka along with her twin Misaki Fujioka until one day Yukiyo Misaki, Mitsuyo's younger twin sister, also became pregnant but miscarried leaving her devastated. At the same time, Mei's family was experiencing financial problems. Because of this, along with the fact that Yukiyo was still trying to cope with the loss of her unborn child, Mitsuyo gave Mei to her sister to raise her as her own daughter.

At some point in her elementary school years, Mei learns that Misaki was her twin after her grandmother accidentally slipped it out resulting in Kirika having another mental breakdown. One night Mei found her "mother" crying and wanted to know the reason, to which Kirika tells her on that night that she was not allowed to meet her biological family, originating where Mei had a cellphone prior before the story began. Despite this, Mei secretly meets her twin sister, and also becomes close friends.

One and a half year before the calamity began, Mei witnessed an unknown assailant killing a young woman from across the river, which she still remembers prior to the story.